BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors:Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells

Thomaz, Amanda and Jaeger, Mariane and Buendia, Marienela and Bambini-Junior, Victorio and Gregianin, Lauro José and Brunetto, Algemir Lunardi and Brunetto, André T and de Farias, Caroline Brunetto and Roesler, Rafael (2016) BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors:Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells. Journal of Molecular Neuroscience, 59 (3). pp. 326-333. ISSN 0895-8696

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Abstract

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling has been associated with increased proliferative capabilities, invasiveness, and chemoresistance in several types of cancer. However, the relevance of this pathway in MB remains unknown. Here, we show that the selective TrkB inhibitor N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide (ANA-12) markedly reduced the viability and survival of human cell lines representative of different MB molecular subgroups. These findings provide the first evidence supporting further investigation of TrkB inhibition as a potential novel strategy for MB treatment.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Molecular Neuroscience
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2804
Subjects:
ID Code:
168522
Deposited By:
Deposited On:
12 Apr 2022 15:45
Refereed?:
Yes
Published?:
Published
Last Modified:
12 Apr 2022 15:45