Geostatistical modelling enables efficient safety assessment for mass drug administration with ivermectin in Loa loa endemic areas through a combined antibody and LoaScope testing strategy for elimination of onchocerciasis

Johnson, Olatunji and Giorgi, Emanuele and Fronterrè, Claudio and Amoah, Benjamin and Atsame, Julienne and Ella, Sylvie Ntsame and Biamonte, Marco and Ogoussan, Kisito and Hundley, Lee and Gass, Katherine and Diggle, Peter J. (2022) Geostatistical modelling enables efficient safety assessment for mass drug administration with ivermectin in Loa loa endemic areas through a combined antibody and LoaScope testing strategy for elimination of onchocerciasis. PLoS Neglected Tropical Diseases, 16 (2). ISSN 1935-2727

Full text not available from this repository.

Abstract

The elimination of onchocerciasis through community-based Mass Drug Administration (MDA) of ivermectin (Mectizan) is hampered by co-endemicity of Loa loa, as individuals who are highly co-infected with Loa loa parasites can suffer serious and occasionally fatal neurological reactions from the drug. The test-and-not-treat strategy of testing all individuals participating in MDA has some operational constraints including the cost and limited availability of LoaScope diagnostic tools. As a result, a Loa loa Antibody (Ab) Rapid Test was developed to offer a complementary way of determining the prevalence of loiasis. We develop a joint geostatistical modelling framework for the analysis of Ab and Loascope data to delineate whether an area is safe for MDA. Our results support the use of a two-stage strategy, in which Ab testing is used to identify areas that, with acceptably high probability, are safe or unsafe for MDA, followed by Loascope testing in areas whose safety status is uncertain. This work therefore contributes to the global effort towards the elimination of onchocerciasis as a public health problem by potentially reducing the time and cost required to establish whether an area is safe for MDA.

Item Type:
Journal Article
Journal or Publication Title:
PLoS Neglected Tropical Diseases
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000
Subjects:
ID Code:
167804
Deposited By:
Deposited On:
22 Mar 2022 11:50
Refereed?:
Yes
Published?:
Published
Last Modified:
04 May 2022 02:45