Bitter brain:Hypoglycemia and the pathology of neurodegeneration and dementia

Balendra, V. and Esposto, J.C. and Reich, N. (2021) Bitter brain:Hypoglycemia and the pathology of neurodegeneration and dementia. Alzheimer's and Dementia : the journal of the Alzheimer's Association, 17 (S3).

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Abstract

BACKGROUND: Glucose poses the predominant energy source of the brain and its continuous uptake is vital for optimal brain function. Neurons metabolize glucose to generate adenosine triphosphate via glycolysis and the tricarboxylic acid cycle, whereas astrocytes utilize glucose both as an energy source and to generate glutamine - a neurotransmitter precursor- for neurons [Brekke et al., 2015]. Here, we prospectively examine the relationship between chronic hypoglycemia and the associated links between neurodegeneration and dementia. It is proposed that severe episodes or chronic hypoglycemia will induce an increased risk of dementia. METHODS: A complex and specific literature search was conducted across various scientific, international databases for English, peer-reviewed articles and reviews published in the last two decades using the following terms: diabetes, insulin, glucose metabolism, hypoglycemia, and Alzheimer's disease (AD). Case reports were excluded. The main objectives were predominantly focused on animal- or human-based studies. RESULTS: When blood glucose levels are

Item Type:
Journal Article
Journal or Publication Title:
Alzheimer's and Dementia : the journal of the Alzheimer's Association
ID Code:
167631
Deposited By:
Deposited On:
17 Mar 2022 09:55
Refereed?:
Yes
Published?:
Published
Last Modified:
04 May 2022 02:43