Chronic obstructive pulmonary disease in sub-Saharan Africa

Awokola, B. I. and Amusa, G. A. and Jewell, C. P. and Okello, G. and Stobrink, M. and Finney, L. J. and Mohammed, N. and Erhart, A. and Mortimer, K. J. (2022) Chronic obstructive pulmonary disease in sub-Saharan Africa. International Journal of Tuberculosis and Lung Disease, 26 (3). pp. 232-242. ISSN 1027-3719

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Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and an important cause of death in sub-Saharan Africa (SSA). We conducted a systematic review and meta-analysis on the prevalence of and risk factors for COPD in SSA.METHODS: We conducted a protocol-driven systematic literature search in MEDLINE, EMBASE, CINAHL and Global Health, supplemented by a manual search of the abstracts from thoracic conference proceedings from 2017 to 2020. We did a meta-analysis of COPD prevalence and its association with current smoking.RESULTS: We identified 831 titles, of which 27 were eligible for inclusion in the review and meta-analysis. The population prevalence of COPD ranged from 1.7% to 24.8% (pooled prevalence: 8%, 95% CI 6–11). An increased prevalence of COPD was associated with increasing age, smoking and biomass smoke exposure. The pooled odds ratio for the effect of current smoking (vs. never smoked) on COPD was 2.20 (95% CI 1.62–2.99).CONCLUSION: COPD causes morbidity and mortality in adults in SSA. Smoking is an important risk factor for COPD in SSA, and this exposure needs to be reduced through the combined efforts of clinicians, researchers and policymakers to address this debilitating and preventable lung disease.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Tuberculosis and Lung Disease
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2740
Subjects:
ID Code:
167212
Deposited By:
Deposited On:
08 Mar 2022 10:45
Refereed?:
Yes
Published?:
Published
Last Modified:
04 May 2022 02:48