Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

Clayton, Emily and Ackerley, Jacob and Aelmans, Marianne and Ali, Noor and Ashcroft, Zoe and Ashton, Clara and Barker, Robert and Budryte, Vakare and Burrows, Callum and Cai, Shanshan and Callaghan, Alex and Carberry, Jake and Chatwin, Rebecca and Davies, Isabella and Farlow, Chloe and Gamblin, Samuel and Iacobut, Aida and Lambe, Adam and Lynch, Francesca and Mihalache, Diana and Mokbel, Amani and Potamsetty, Santosh and Qadir, Zara and Soden, Jack and Sun, Xiaohan and Vasile, Alexandru and Wheeler, Otto and Rohaim, Mohammed A. and Munir, Muhammad (2022) Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. Viruses, 14 (2). ISSN 1999-4915

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The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.

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17 Jun 2022 13:25
Last Modified:
20 Sep 2023 01:49