The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation

Galeb, Hanaa and Lamantia, Angelo and Robson, Alexander and König, Katja and Eichhorn, Jonas and Baldock, Sara and Ashton, Mark and Baum, John and Mort, Richard and Robinson, Benjamin and Schacher, Felix and Chechik, Victor and Taylor, Adam and Hardy, John (2022) The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation. Macromolecular Chemistry and Physics, 223 (6). ISSN 1022-1352

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Abstract

Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.

Item Type:
Journal Article
Journal or Publication Title:
Macromolecular Chemistry and Physics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1606
Subjects:
ID Code:
166080
Deposited By:
Deposited On:
14 Feb 2022 11:35
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jun 2022 00:42