The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation

Galeb, Hanaa and Lamantia, Angelo and Robson, Alexander and König, Katja and Eichhorn, Jonas and Baldock, Sara and Ashton, Mark and Baum, John and Mort, Richard and Robinson, Benjamin and Schacher, Felix and Chechik, Victor and Taylor, Adam and Hardy, John (2022) The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation. Macromolecular Chemistry and Physics, 223 (6). ISSN 1022-1352

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Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.

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Journal Article
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Macromolecular Chemistry and Physics
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Deposited On:
14 Feb 2022 11:35
Last Modified:
02 Mar 2023 15:35