Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2

Burnett, Joseph and Li, Jianwei and McCue, Alan and Kechagiopoulos, Panagiotis N. and Howe, Russell F. and Wang, Xiaodong (2022) Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2. Green Chemistry, 24 (4). pp. 1451-1455. ISSN 1463-9262

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H2-driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at.% Sn can deliver a selectivity of 90% (at ~100% conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4- position of the nicotinamide ring.

Item Type:
Journal Article
Journal or Publication Title:
Green Chemistry
Uncontrolled Keywords:
?? environmental chemistrypollution ??
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Deposited On:
31 Jan 2022 12:10
Last Modified:
28 May 2024 11:27