The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds

Abalymov, Anatoly and Lengert, Ekaterina and Van der Meeren, Louis and Saveleva, Mariia and Ivanova, Anna and Douglas, Timothy and Douglas, E. L. and Skirtach, Andre G. and Volodkin, Dmitry and Parakhonskiy, Bogdan V (2022) The influence of Ca/Mg ratio on autogelation of hydrogel biomaterials with bioceramic compounds. Materials Science and Engineering: C, 133: 112632. ISSN 0928-4931

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Hydrogels, which are versatile three-dimensional structures containing polymers and water, are very attractive for use in biomedical fields, but they suffer from rather weak mechanical properties. In this regard, biocompatible particles can be used to enhance their mechanical properties. The possibility of loading such particles with drugs (e.g. enzymes) makes them a particularly useful component in hydrogels. In this study, micro/nanoparticles containing various ratios of Ca /Mg with sizes ranging from 1 to 8 μm were prepared and mixed with gellan gum (GG) solution to study the in-situ formation of hydrogel-particle composites. The particles provide multiple functionalities: 1) they efficiently crosslink GG to induce hydrogel formation through the release of the divalent cations (Ca /Mg ) known to bind to GG polymer chains; 2) they enhance mechanical properties of the hydrogel from 2 up to 100 kPa; 3) the samples most efficiently promoting cell growth were found to contain two types of minerals: vaterite and hydroxymagnesite, which enhanced cells proliferation and hydroxyapatite formation. The results demonstrate that such composite materials are attractive candidates for applications in bone regeneration.

Item Type:
Journal Article
Journal or Publication Title:
Materials Science and Engineering: C
Additional Information:
This is the author’s version of a work that was accepted for publication in Biomaterial Advances. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterial Advances, 133, 112632, 2022 DOI: 10.1016/j.msec.2021.112632
Uncontrolled Keywords:
?? caclium carbonatevateritehydrogelcellsgellificationgellun gumossificationhydroxyapatitemechanics of materialsmaterials science(all)mechanical engineeringcondensed matter physics ??
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Deposited On:
21 Dec 2021 09:20
Last Modified:
04 Jan 2024 00:25