Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4

Olmo, Roenick P. and Todjro, Yaovi M. H. and Aguiar, Eric R. G. R. and de Almeida, João Paulo P. and Armache, Juliana N. and de Faria, Isaque J. S. and Ferreira, Flávia V. and Silva, Ana Teresa S. and de Souza, Kátia P. R. and Vilela, Ana Paula P. and Tan, Cheong H. and Diallo, Mawlouth and Gaye, Alioune and Paupy, Christophe and Obame-Nkoghe, Judicaël and Visser, Tessa M. and Koenraadt, Constantianus J. M. and Wongsokarijo, Merril A. and Cruz, Ana Luiza C. and Prieto, Mariliza T. and Parra, Maisa C. P. and Nogueira, Maurício L. and Avelino-Silva, Vivian and Mota, Renato N. and Borges, Magno A. Z. and Drumond, Betânia P. and Kroon, Erna G. and Sedda, Luigi and Marois, Eric and Imler, Jean-Luc and Marques, João T. (2021) Insect-specific viruses regulate vector competence in <em>Aedes aegypti</em> mosquitoes via expression of histone H4. Biorxiv. 2021.06.05.447047.

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Aedes aegypti and Aedes albopictus are major mosquito vectors for arthropod-borne viruses (arboviruses) such as dengue (DENV) and Zika (ZIKV) viruses. Mosquitoes also carry insect-specific viruses (ISVs) that may affect the transmission of arboviruses. Here, we analyzed the global virome in urban Aedes mosquitoes and observed that two insect-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most prevalent in A. aegypti worldwide except for African cities, where transmission of arboviruses is low. Spatiotemporal analysis revealed that presence of HTV and PCLV led to a 200% increase in the chances of having DENV in wild mosquitoes. In the laboratory, we showed that HTV and PCLV prevented downregulation of histone H4, a previously unrecognized proviral host factor, and rendered mosquitoes more susceptible to DENV and ZIKV. Altogether, our data reveals a molecular basis for the regulation of A. aegypti vector competence by highly prevalent ISVs that may impact how we analyze the risk of arbovirus outbreaks.

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18 Oct 2021 15:50
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21 Sep 2023 03:10