Predicting virologically confirmed influenza using school absences in Allegheny County, Pennsylvania, USA during the 2007-2015 influenza seasons

Quandelacy, T.M. and Zimmer, S. and Lessler, J. and Vukotich, C. and Bieltz, R. and Grantz, K.H. and Galloway, D. and Read, J.M. and Zheteyeva, Y. and Gao, H. and Uzicanin, A. and Cummings, D.A.T. (2021) Predicting virologically confirmed influenza using school absences in Allegheny County, Pennsylvania, USA during the 2007-2015 influenza seasons. Influenza and Other Respiratory Viruses. ISSN 1750-2640

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Abstract

Background: Children are important in community-level influenza transmission. School-based monitoring may inform influenza surveillance. Methods: We used reported weekly confirmed influenza in Allegheny County during the 2007 and 2010-2015 influenza seasons using Pennsylvania's Allegheny County Health Department all-age influenza cases from health facilities, and all-cause and influenza-like illness (ILI)-specific absences from nine county school districts. Negative binomial regression predicted influenza cases using all-cause and illness-specific absence rates, calendar week, average weekly temperature, and relative humidity, using four cross-validations. Results: School districts reported 2 184 220 all-cause absences (2010-2015). Three one-season studies reported 19 577 all-cause and 3012 ILI-related absences (2007, 2012, 2015). Over seven seasons, 11 946 confirmed influenza cases were reported. Absences improved seasonal model fits and predictions. Multivariate models using elementary school absences outperformed middle and high school models (relative mean absolute error (relMAE) = 0.94, 0.98, 0.99). K-5 grade-specific absence models had lowest mean absolute errors (MAE) in cross-validations. ILI-specific absences performed marginally better than all-cause absences in two years, adjusting for other covariates, but markedly worse one year. Conclusions: Our findings suggest seasonal models including K-5th grade absences predict all-age-confirmed influenza and may serve as a useful surveillance tool.

Item Type:
Journal Article
Journal or Publication Title:
Influenza and Other Respiratory Viruses
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2740
Subjects:
ID Code:
159731
Deposited By:
Deposited On:
17 Sep 2021 10:43
Refereed?:
Yes
Published?:
Published
Last Modified:
06 Oct 2021 08:28