MIDA–Vinylsilanes : Selective Cross-Couplings and Applications to the Synthesis of Functionalized Stilbenes

McLaughlin, Mark and McAdam, C.A. and Cook, Matthew J. (2015) MIDA–Vinylsilanes : Selective Cross-Couplings and Applications to the Synthesis of Functionalized Stilbenes. Organic Letters, 17 (1). pp. 10-13. ISSN 1523-7060

Abstract

A rapid and stereodefined synthesis of MIDA–boryl vinylsilanes has been achieved through the hydrosilylation of an alkynylboronic ester. The E products which contain a silyl and boryl group can be selectively cross-coupled in a two-step bidirectional sequence to provide a rapid and high-yielding synthesis of complex styrenes.