Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions

Basson, Ashley J. and McLaughlin, Mark G. (2020) Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions. The Journal of Organic Chemistry, 85 (8). pp. 5615-5628.

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Abstract

Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.

Item Type:
Journal Article
Journal or Publication Title:
The Journal of Organic Chemistry
ID Code:
158597
Deposited By:
Deposited On:
08 Sep 2021 11:05
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Oct 2021 06:10