Gatherer, Derek and Depledge, Daniel P and Hartley, Carol and Szpara, Moriah L and Vaz, Paola and Benko, Maria and Brandt, Curtis and Bryant, Neil and Dastjerdi, Akbar and Doszpoly, Andor and Gompels, Ursula and Inoue, Naoki and Jarosinski, Keith and Kaul, Rajeev and Lacoste, Vincent and Norberg, Peter and Origgi, Francesco and Orton, Richard and Pellett, Philip and Schmid, Scott and Spatz, Stephen and Stewart, James P and Trimpert, Jakob and Waltzek, Thomas B and Davison, Andrew J. (2021) Herpesviridae. Journal of General Virology, 102 (10). ISSN 0022-1317
Full text not available from this repository.Abstract
Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components (Table 1.Herpesviridae). The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 genes, of which 43 have been inherited from an ancestral herpesvirus. Herpesviruses have generally coevolved with their hosts and are highly adapted to them, and are likely to be associated with most mammalian, avian and reptilian species. Following primary infection, they are able to establish life-long latent infection, during which there is limited viral gene expression. Severe disease is usually observed only in the foetus, the very young, the immunocompromised or following infection of an alternative host.