Towards the Translation of Electroconductive Organic Materials for Regeneration of Neural Tissues

Manousiouthakis, Eleana and Park, Junggeon and Hardy, John and Lee, Jae and Schmidt, Christine (2022) Towards the Translation of Electroconductive Organic Materials for Regeneration of Neural Tissues. Acta Biomaterialia, 139. pp. 22-42. ISSN 1742-7061

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Abstract

Carbon-based conductive and electroactive materials (e.g., derivatives of graphene, fullerenes, polypyrrole, polythiophene, polyaniline) have been studied since the 1970s for use in a broad range of applications. These materials have electrical properties comparable to those of commonly used metals, while providing other benefits such as flexibility in processing and modification with biologics (e.g., cells, biomolecules), to yield electroactive materials with biomimetic mechanical and chemical properties. In this review, we focus on the uses of these electroconductive materials in the context of the central and peripheral nervous system, specifically recent studies in the peripheral nerve, spinal cord, brain, eye, and ear. We also highlight in vivo studies and clinical trials, as well as a snapshot of emerging classes of electroconductive materials (e.g., biodegradable materials). We believe such specialized electrically conductive biomaterials will clinically impact the field of tissue regeneration in the foreseeable future.