International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease

Laansma, M.A. and Bright, J.K. and Al-Bachari, S. and Anderson, T.J. and Ard, T. and Assogna, F. and Baquero, K.A. and Berendse, H.W. and Blair, J. and Cendes, F. and Dalrymple-Alford, J.C. and de Bie, R.M.A. and Debove, I. and Dirkx, M.F. and Druzgal, J. and Emsley, H.C.A. and Garraux, G. and Guimarães, R.P. and Gutman, B.A. and Helmich, R.C. and Klein, J.C. and Mackay, C.E. and McMillan, C.T. and Melzer, T.R. and Parkes, L.M. and Piras, F. and Pitcher, T.L. and Poston, K.L. and Rango, M. and Ribeiro, L.F. and Rocha, C.S. and Rummel, C. and Santos, L.S.R. and Schmidt, R. and Schwingenschuh, P. and Spalletta, G. and Squarcina, L. and van den Heuvel, O.A. and Vriend, C. and Wang, J.-J. and Weintraub, D. and Wiest, R. and Yasuda, C.L. and Jahanshad, N. and Thompson, P.M. and van der Werf, Y.D. and Study, The ENIGMA-Parkinson's (2021) International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease. Movement Disorders, 36 (11). pp. 2583-2594. ISSN 0885-3185

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Background: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. Methods: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. Results: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax = −0.20, dmin = −0.09). The bilateral putamen (dleft = −0.14, dright = −0.14) and left amygdala (d = −0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. Conclusions: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations.

Item Type:
Journal Article
Journal or Publication Title:
Movement Disorders
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Deposited On:
27 Aug 2021 15:25
Last Modified:
15 Sep 2023 04:38