Electrical Stimulation to Enhance Wound Healing

Rajendran, Saranya and Challen, Kirsty and Wright, Karen and Hardy, John (2021) Electrical Stimulation to Enhance Wound Healing. Journal of Functional Biomaterials, 12 (2). ISSN 2079-4983

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Abstract

Electrical stimulation (ES) can serve as a therapeutic modality accelerating the healing of wounds, particularly chronic wounds which have impaired healing due to complications from underlying pathology. This review explores how ES affects the cellular mechanisms of wound healing, and its effectiveness in treating acute and chronic wounds. Literature searches with no publication date restrictions were conducted using the Cochrane Library, Medline, Web of Science, Google Scholar and PubMed databases, and 30 full-text articles met the inclusion criteria. In vitro and in vivo experiments investigating the effect of ES on the general mechanisms of healing demonstrated increased epithelialization, fibroblast migration, and vascularity around wounds. Six in vitro studies demonstrated bactericidal effects upon exposure to alternating and pulsed current. Twelve randomized controlled trials (RCTs) investigated the effect of pulsed current on chronic wound healing. All reviewed RCTs demonstrated a larger reduction in wound size and increased healing rate when compared to control groups. In conclusion, ES therapy can contribute to improved chronic wound healing and potentially reduce the financial burden associated with wound management. However, the variations in the wound characteristics, patient demographics, and ES parameters used across studies present opportunities for systematic RCT studies in the future.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Functional Biomaterials
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2200/2204
Subjects:
ID Code:
156352
Deposited By:
Deposited On:
21 Jun 2021 07:50
Refereed?:
Yes
Published?:
Published
Last Modified:
25 Oct 2021 04:49