The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat

Fu, G. and Dai, J. and Li, Z. and Chen, F. and Liu, L. and Yi, L. and Teng, Z. and Quan, C. and Zhang, L. and Zhou, T. and Donkersley, P. and Song, S. and Shi, Y. (2020) The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. Toxicology and Applied Pharmacology, 404. ISSN 0041-008X

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Abstract

Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor that impairs development of testis and spermatogenesis. This study aims to explore the effects of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat. 24 6-week-old male Sprague-Dawley rats were randomly divided into 4 groups (Control, low-dose, middle-dose and high-dose group) and were treated with increasing concentration of DEHP (0, 250, 500, 1000 mg/kg/day) respectively for 28 consecutive days by intragastric administration. Our results showed that DEHP exposure induced obvious morphological changes of testis, decreased organ coefficient of testis and sperm count, and increased testicular cell apoptosis in the 500 and 1000 mg/kg/day DEHP groups.

Item Type:
Journal Article
Journal or Publication Title:
Toxicology and Applied Pharmacology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3004
Subjects:
ID Code:
155573
Deposited By:
Deposited On:
01 Jun 2021 14:40
Refereed?:
Yes
Published?:
Published
Last Modified:
27 Jul 2021 05:45