Biological therapy in patients with rheumatoid arthritis in a tertiary center in portugal:A cross-sectional study

FERNANDES, Melissa and FIGUEIREDO, Adelaide and OLIVEIRA, Ana Luísa and FERREIRA, Ana Carolina and MENDONÇA, Pedro and TAULAIGO, Anna V. and VICENTE, Madalena and FANICA, Maria João and RUANO, Carina and PANARRA, António and MATEUS, Céu and MORAES-FONTES, Maria Francisca (2021) Biological therapy in patients with rheumatoid arthritis in a tertiary center in portugal:A cross-sectional study. Acta Medica Portuguesa, 34 (5). pp. 362-371. ISSN 0870-399X

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Abstract

Introduction: Clinical outcomes in rheumatoid arthritis have greatly improved with therapeutic advances. Despite the availability of substantial clinical trial evidence, there is a lack of real-life data. The aim of this study was to assess disease status and quality of life in an outpatient population treated with biological disease-modifying anti-rheumatic drugs. Material and Methods: Cross-sectional study recalling all patients ever treated in our unit with biological disease-modifying anti-rheumatic drugs. Clinical and demographic data, compliance, disease activity, functional status, joint deformities, and comorbidities were documented, and patients queried on occupational status, education, marital status and generic health related quality of life questionnaires. Results: Recall was attended by 77 of the original 94 patients. At recall, median age was 63 years old, 82% of the patients were female and the median disease duration was 12 years. Biological therapy was started at a median of four years following disease onset. According to the disease activity score (DAS28), the percentage of patients with high, moderate, low disease activity or remission changed from 50, 45, 0 and 5 (pre-therapy) to 11, 37, 25 and 26 at recall, respectively; functional status was significantly improved. Seventy-five per cent of the patients retained the original treatment with good compliance. Lower Short Form-36 domain scores accompanied a low EQ-5D-3L score. Deceased patients (n = 6) had a lower estimated 10-year survival rate. In this group, biological therapy was discontinued at a higher frequency during follow-up. Discussion: A high disease activity and a high HAQ disability index characterized most patients at pre-bDMARD onset. Conclusion: Despite therapy switches and regular follow-up, a significant percentage of patients still presented with moderate disease activity, functional impairment and a poor health-related quality of life.

Item Type:
Journal Article
Journal or Publication Title:
Acta Medica Portuguesa
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
153788
Deposited By:
Deposited On:
16 Apr 2021 09:35
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Nov 2021 16:20