Recruitment prediction for multicenter clinical trials based on a hierarchical Poisson–gamma model: Asymptotic analysis and improved intervals:Asymptotic analysis and improved intervals

Mountain, Rachael and Sherlock, Chris (2022) Recruitment prediction for multicenter clinical trials based on a hierarchical Poisson–gamma model: Asymptotic analysis and improved intervals:Asymptotic analysis and improved intervals. Biometrics, 78 (2). pp. 636-648. ISSN 0006-341X

Full text not available from this repository.

Abstract

We analyze predictions of future recruitment to a multicenter clinical trial based on a maximum-likelihood fitting of a commonly used hierarchical Poisson–gamma model for recruitments at individual centers. We consider the asymptotic accuracy of quantile predictions in the limit as the number of recruitment centers grows large and find that, in an important sense, the accuracy of the quantiles does not improve as the number of centers increases. When predicting the number of further recruits in an additional time period, the accuracy degrades as the ratio of the additional time to the census time increases, whereas when predicting the amount of additional time to recruit a further n+• patients, the accuracy degrades as the ratio of n+• to the number recruited up to the census period increases. Our analysis suggests an improved quantile predictor. Simulation studies verify that the predicted pattern holds for typical recruitment scenarios in clinical trials and verify the much improved coverage properties of prediction intervals obtained from our quantile predictor. In the process of extending the applicability of our methodology, we show that in terms of the accuracy of all integer moments it is always better to approximate the sum of independent gamma random variables by a single gamma random variable matched on the first two moments than by the moment-matched Gaussian available from the central limit theorem

Item Type:
Journal Article
Journal or Publication Title:
Biometrics
Additional Information:
This is the peer reviewed version of the following article: Rachael Mountain, Chris Sherlock (2021), Recruitment prediction for multicenter clinical trials based on a hierarchical Poisson–gamma model: Asymptotic analysis and improved intervals. BIOMETRIC METHODOLOGY. doi: 10.1111/biom.13447 which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1111/biom.13447 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
151671
Deposited By:
Deposited On:
12 Feb 2021 13:00
Refereed?:
Yes
Published?:
Published
Last Modified:
18 Jul 2022 08:40