A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus

Wunder, E.A. and Adhikarla, H. and Hamond, C. and Bonner, K.A.O. and Liang, L. and Rodrigues, C.B. and Bisht, V. and Nally, J.E. and Alt, D.P. and Reis, M.G. and Diggle, P.J. and Felgner, P.L. and Ko, A. (2021) A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus. eLife, 10. pp. 1-20. ISSN 2050-084X

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Abstract

Leptospirosis is the leading zoonotic disease in terms of morbidity and mortality worldwide. Effective prevention is urgently needed as the drivers of disease transmission continue to intensify. The key challenge has been developing a widely applicable vaccine that protects against the >300 serovars that can cause leptospirosis. Live attenuated mutants are enticing vaccine candidates and poorly explored in the field. We evaluated a recently characterized motility-deficient mutant lacking the expression of a flagellar protein, FcpA. Although the fcpA- mutant has lost its ability to cause disease, transient bacteremia was observed. In two animal models, immunization with a single dose of the fcpA- mutant was sufficient to induce a robust anti-protein antibodies response that promoted protection against infection with different pathogenic Leptospira species. Furthermore, characterization of the immune response identified a small repertoire of biologically relevant proteins that are highly conserved among pathogenic Leptospira species and potential correlates of cross-protective immunity. © 2021, eLife Sciences Publications Ltd. All rights reserved.

Item Type:
Journal Article
Journal or Publication Title:
eLife
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800
Subjects:
ID Code:
151581
Deposited By:
Deposited On:
16 Feb 2021 13:51
Refereed?:
Yes
Published?:
Published
Last Modified:
06 Jul 2021 09:30