Late-onset epilepsy predicts stroke : Systematic review and meta-analysis

Wall, Jasmine and Knight, Jo and Emsley, Hedley C.A. (2021) Late-onset epilepsy predicts stroke : Systematic review and meta-analysis. Epilepsy and Behavior, 115: 107634. ISSN 1525-5050

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Objective: Late-onset epilepsy (LOE) is closely associated with cerebrovascular disease, acting as both a marker of cerebrovascular disease (CVD) and occurring as a direct consequence. Despite this, our understanding of LOE as a cerebrovascular phenomenon is in its infancy. LOE also appears to be a harbinger of dementia. Methods: A systematic review was performed to identify publications relating to LOE and identified observational studies, clinical studies, and radiological studies. Results: A meta-analysis of observational studies demonstrated that patients presenting with LOE experience an increased risk of subsequent stroke (weighted OR 3.88 (95% CI 2.76–5.46)). The additional studies demonstrated clinical and radiological evidence to support the premise that LOE is likely to reflect underlying cerebrovascular disease. Significance: Cerebrovascular disease risk factors convey increased risk of LOE and LOE can precede stroke and dementia, acting as an early marker for cerebrovascular risk. This may represent a potential point for intervention. There are a number of suggested mechanisms relating LOE to stroke; however, there is limited understanding of the natural history of LOE. Current data support the need for prospective research in order to understand the natural history of LOE and modify disease, in order to reduce the apparent sequelae of stroke and dementia.

Item Type:
Journal Article
Journal or Publication Title:
Epilepsy and Behavior
Additional Information:
This is the author’s version of a work that was accepted for publication in Epilepsy and Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Epilepsy and Behavior, 115, 2021 DOI: 10.1016/j.yebeh.2020.107634
Uncontrolled Keywords:
?? alzheimer's dementialate-onset epilepsylate-onset seizurevascular dementiawhite matter lesionsneurologyclinical neurologybehavioral neuroscience ??
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Deposited On:
05 Feb 2021 10:55
Last Modified:
15 Jul 2024 21:18