Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus

Pałasz, A. and Suszka-Świtek, A. and Kaśkosz, A. and Plewka, D. and Bogus, K. and Filipczyk, Ł. and Błaszczyk, I. and Bacopoulou, F. and Worthington, J.J. and Piwowarczyk-Nowak, A. and Tyszkiewicz-Nwafor, M. and Wiaderkiewicz, R. (2021) Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus. Journal of Chemical Neuroanatomy, 111.

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Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain. © 2020 Elsevier B.V.

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Journal Article
Journal or Publication Title:
Journal of Chemical Neuroanatomy
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This is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, 111, 2020 DOI: 10.1016/j.jchemneu.2020.101883
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Deposited On:
07 Dec 2020 12:05
Last Modified:
19 Sep 2023 02:32