Aggregation and adhesion of gold nanoparticles in phosphate buffered saline

Du, Shangfeng and Kendall, Kevin and Toloueinia, Panteha and Mehrabadi, Yasamin and Gupta, Gaurav and Newton, Jill (2012) Aggregation and adhesion of gold nanoparticles in phosphate buffered saline. Journal of Nanoparticle Research, 14. ISSN 1388-0764

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In applications in medicine and more specifically drug delivery, the dispersion stability of nanoparticles plays a significant role on their final performances. In this study, with the use of two laser technologies, dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA), we report a simple method to estimate the stability of nanoparticles dispersed in phosphate buffered saline (PBS). Stability has two features: (1) self-aggregation as the particles tend to stick to each other; (2) disappearance of particles as they adhere to surrounding substrate surfaces such as glass, metal, or polymer. By investigating the effects of sonication treatment and surface modification by five types of surfactants, including nonylphenol ethoxylate (NP9), polyvinyl pyrrolidone (PVP), human serum albumin (HSA), sodium dodecyl sulfate (SDS) and citrate ions on the dispersion stability, the varying self-aggregation and adhesion of gold nanoparticles dispersed in PBS are demonstrated. The results showed that PVP effectively prevented aggregation, while HSA exhibited the best performance in avoiding the adhesion of gold nanoparticle in PBS onto glass and metal. The simple principle of this method makes it a high potential to be applied to other nanoparticles, including virus particles, used in dispersing and processing.

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Journal Article
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Journal of Nanoparticle Research
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10 Aug 2020 15:15
Last Modified:
22 Nov 2022 09:22