Serum CA72-4 is specifically elevated in gout patients and predicts flares

Bai, Xueshan and Sun, Mingshu and He, Yuwei and Liu, Ruhua and Cui, Lingling and Wang, Can and Wan, Fang and Wang, Ming and Li, Xinde and Li, Hailong and Wu, Xinjiang and Li, Changgui (2020) Serum CA72-4 is specifically elevated in gout patients and predicts flares. Rheumatology. ISSN 1462-0324

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Abstract

Objectives Serum CA72-4 levels are elevated in some gout patients but this has not been comprehensively described. The present study profiled serum CA72-4 expression in gout patients and verified the hypothesis that CA72-4 is a predictor of future flares in a prospective gout cohort. Methods To profile CA72-4 expression, a cross-sectional study was conducted in subjects with gouty arthritis, asymptomatic hyperuricaemia, four major arthritis types (OA, RA, SpA, septic arthritis) and healthy controls. A prospective gout cohort study was initiated to test the value of CA72-4 for predicting gout flares. During a 6-month follow-up, gout flares, CA72-4 levels and other gout-related clinical variables were observed at 1, 3 and 6 months. Results CA72-4 was highly expressed in patients with gouty arthritis [median (interquartile range) 4.55 (1.56, 32.64) U/ml] compared with hyperuricaemia patients [1.47 (0.87, 3.29) U/ml], healthy subjects [1.59 (0.99, 3.39) U/ml] and other arthritis patients [septic arthritis, 1.38 (0.99, 2.66) U/ml; RA, 1.58 (0.95, 3.37) U/ml; SpA, 1.56 (0.98, 2.85) U/ml; OA, 1.54 (0.94, 3.34) U/ml; P < 0.001, respectively]. Gout patients with frequent flares (twice or more in the last year) had higher CA72-4 levels than patients with fewer flares (fewer than twice in the last year). High CA72-4 level (>6.9 U/ml) was the strongest predictor of gout flares (hazard ratio = 3.889). Prophylactic colchicine was effective, especially for patients with high CA72-4 levels (P = 0.014). Conclusion CA72-4 levels were upregulated in gout patients who experienced frequent flares and CA72-4 was a useful biomarker to predict future flares.

Item Type:
Journal Article
Journal or Publication Title:
Rheumatology
Additional Information:
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version Xueshan Bai, Mingshu Sun, Yuwei He, Ruhua Liu, Lingling Cui, Can Wang, Fang Wan, Ming Wang, Xinde Li, Hailong Li, Xinjiang Wu, Changgui Li, Serum CA72-4 is specifically elevated in gout patients and predicts flares, Rheumatology, , keaa046, https://doi.org/10.1093/rheumatology/keaa046 is available online at:
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2736
Subjects:
ID Code:
144389
Deposited By:
Deposited On:
03 Jun 2020 09:55
Refereed?:
Yes
Published?:
Published
Last Modified:
21 Sep 2020 00:22