XPA:DNA repair protein of significant clinical importance

Pulzová, L.B. and Ward, T.A. and Chovanec, M. (2020) XPA:DNA repair protein of significant clinical importance. International Journal of Molecular Sciences, 21 (6). ISSN 1661-6596

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Abstract

The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic agents. Expression levels of NER factors and resistance to chemotherapy has been examined with some suggestion that NER plays a role in tumour resistance; however, there is a great degree of variability in these studies. Nevertheless, recent clinical studies have suggested Xeroderma Pigmentosum group A (XPA) protein, a key regulator of the NER pathway that is essential for the repair of DNA damage induced by platinum-based chemotherapeutics, as a potential prognostic and predictive biomarker for response to treatment. XPA functions in damage verification step in NER, as well as a molecular scaffold to assemble other NER core factors around the DNA damage site, mediated by protein–protein interactions. In this review, we focus on the interacting partners and mechanisms of regulation of the XPA protein. We summarize clinical oncology data related to this DNA repair factor, particularly its relationship with treatment outcome, and examine the potential of XPA as a target for small molecule inhibitors.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Molecular Sciences
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1700/1706
Subjects:
ID Code:
143233
Deposited By:
Deposited On:
20 Apr 2020 13:40
Refereed?:
Yes
Published?:
Published
Last Modified:
06 Jul 2020 01:41