The first Non-LRV RNA virus in leishmania

Grybchuk, D. and MacEdo, D.H. and Kleschenko, Y. and Kraeva, N. and Lukashev, A.N. and Bates, P.A. and Kulich, P. and Leštinová, T. and Volf, P. and Kostygov, A.Y. and Yurchenko, V. (2020) The first Non-LRV RNA virus in leishmania. Viruses, 12 (2). ISSN 1999-4915

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Abstract

In this work, we describe the first Leishmania-infecting leishbunyavirus—the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites’ infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species.

Item Type:
Journal Article
Journal or Publication Title:
Viruses
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2725
Subjects:
ID Code:
141390
Deposited By:
Deposited On:
13 Feb 2020 09:50
Refereed?:
Yes
Published?:
Published
Last Modified:
13 Sep 2020 16:55