Refractory pruritus from malignant cholestasis:Management

Gunasekara Vidana Mestrige Fernando, Chamath and Preston, Nancy (2020) Refractory pruritus from malignant cholestasis:Management. BMJ Supportive and Palliative Care. ISSN 2045-435X

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Abstract

This case report deals with a patient managed in a tertiary-care cancer hospital who suffered pruritus associated with malignant cholestasis. His symptoms were resistant to conventional treatment with ursodeoxycholic acid, chlorpheniramine and cholestyramine. Hence, the multifactorial origin of malignancy-associated pruritus was considered. Correctable factors were corrected and generally the treatment was aimed at possible aetiologies. There were barriers related to insufficient resources available for symptom palliation in this particular setting, which could potentially reduce optimum symptom control. However, various pharmacotherapies and non-pharmacological measures which could potentially have helped relieve pruritus are described and future scope for research in this area discussed.

Item Type:
Journal Article
Journal or Publication Title:
BMJ Supportive and Palliative Care
Additional Information:
This article has been accepted for publication in BMJ Supportive & Palliative Care, 2020 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmjspcare-2019-002051 © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org BMJ Authors Self-Archiving Policy, September 2018 https://creativecommons.org/licenses/by-nc/4.0/
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
140820
Deposited By:
Deposited On:
27 Jan 2020 10:05
Refereed?:
Yes
Published?:
Published
Last Modified:
05 Dec 2020 06:11