Robust and adaptive anticoagulant control

Avery, Peter and Clairon, Quentin and Henderson, Robin and Taylor, C. James and Wilson, Emma (2020) Robust and adaptive anticoagulant control. Journal of the Royal Statistical Society: Series C (Applied Statistics). ISSN 0035-9254 (In Press)

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Abstract

We consider a control theory approach to adaptive dose allocation of anticoagulants, based on an analysis of records of 152 patients on long-term warfarin treatment. We consider a selection of statistical models for the relationship between dose of drug and subsequent blood clotting speed, measured through the International Normalised Ratio. Our main focus is on subsequent use of the model in guiding choice of the next dose adaptively as patient-specific information accrues. We compare a naive myopic approach with a proportional integral plus method, with parameters estimated by either linear quadratic optimisation or by stochastic resource allocation. We demonstrate advantages of the control approaches in comparison to naive in simulations and through calculation of robust stability margins for the observed data.

Item Type: Journal Article
Journal or Publication Title: Journal of the Royal Statistical Society: Series C (Applied Statistics)
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1800/1804
Subjects:
Departments: Faculty of Science and Technology > Engineering
Faculty of Science and Technology > School of Computing & Communications
ID Code: 140423
Deposited By: ep_importer_pure
Deposited On: 16 Jan 2020 16:45
Refereed?: Yes
Published?: In Press
Last Modified: 27 Feb 2020 05:19
URI: https://eprints.lancs.ac.uk/id/eprint/140423

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