A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease

Foulds, PG and Diggle, P and Mitchell, JD and Parker, A and Hasegawa, M and Masuda-Suzukake, M and Mann, DM and Allsop, D (2013) A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease. Scientific Reports, 3. ISSN 2045-2322

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Abstract

There have been no longitudinal studies on α-synuclein as a potential biomarker for the progression of Parkinson's disease (PD). Here, blood plasma ‘total α-synuclein’ and ‘Ser-129 phosphorylated α-synuclein’ were assayed at 4–6 monthly intervals from a cohort of 189 newly-diagnosed patients with PD. For log-transformed data, plasma total α-synuclein levels increased with time for up to 20 yrs after the appearance of initial symptoms (p = 0.012), whereas phosphorylated α-synuclein remained constant over this same period. The mean level of phosphorylated α-synuclein, but not of total α-synuclein, was higher in the PD plasma samples taken at first visit than in single samples taken from a group of 91 healthy controls (p = 0.012). Overall, we conclude that the plasma level of phosphorylated α-synuclein has potential value as a diagnostic tool, whereas the level of total α-synuclein could act as a surrogate marker for the progression of PD.

Item Type: Journal Article
Journal or Publication Title: Scientific Reports
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1000
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
Faculty of Health and Medicine > Medicine
Faculty of Science and Technology > Engineering
Faculty of Arts & Social Sciences > Lancaster Institute for the Contemporary Arts
ID Code: 140340
Deposited By: ep_importer_pure
Deposited On: 14 Jan 2020 14:20
Refereed?: Yes
Published?: Published
Last Modified: 15 Jan 2020 05:38
URI: https://eprints.lancs.ac.uk/id/eprint/140340

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