De Rycker, M. and Horn, D. and Aldridge, B. and Amewu, R.K. and Barry, C.E. and Buckner, F.S. and Cook, S. and Ferguson, M.A.J. and Gobeau, N. and Herrmann, J. and Herrling, P. and Hope, W. and Keiser, J. and Lafuente-Monasterio, M.J. and Leeson, P.D. and Leroy, D. and Manjunatha, U.H. and McCarthy, J. and Miles, T.J. and Mizrahi, V. and Moshynets, O. and Niles, J. and Overington, J.P. and Pottage, J. and Rao, S.P.S. and Read, K.D. and Ribeiro, I. and Silver, L.L. and Southern, J. and Spangenberg, T. and Sundar, S. and Taylor, C. and Van Voorhis, W. and White, N.J. and Wyllie, S. and Wyatt, P.G. and Gilbert, I.H. (2020) Setting Our Sights on Infectious Diseases. ACS Infectious Diseases, 6 (1). pp. 3-13.
Full text not available from this repository.Abstract
In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.