Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Patenall, B.L. and Williams‡, G.T. and Gwynne, L. and Stephens, L.J. and Lampard, E.V. and Hathaway, H.J. and Thet, N.T. and Young, A.E. and Sutton, M.J. and Short, R.D. and Bull, S.D. and James, T.D. and Sedgwick, A.C. and Jenkins, A.T.A. (2019) Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition. Chemical Communications, 55 (100). pp. 15129-15132. ISSN 1359-7345

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Abstract

Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.

Item Type:
Journal Article
Journal or Publication Title:
Chemical Communications
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2500/2504
Subjects:
ID Code:
140011
Deposited By:
Deposited On:
10 Jan 2020 15:25
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Oct 2020 08:04