Race-specific differences in the phase coherence between blood flow and oxygenation : A simultaneous NIRS, white light spectroscopy and LDF study

Abdulhameed, Yunus A. and McClintock, Peter V. E. and Stefanovska, Aneta (2020) Race-specific differences in the phase coherence between blood flow and oxygenation : A simultaneous NIRS, white light spectroscopy and LDF study. Journal of Biophotonics, 13 (4): 201960131. ISSN 1864-063X

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Abstract

Race-specific differences in the level of glycated hemoglobin are well known. However, these differences were detected by invasive measurement of mean oxygenation, and their understanding remains far from complete. Given that oxygen is delivered to the cells by hemoglobin through the cardiovascular system, a possible approach is to investigate the phase coherence between blood flow and oxygen transportation. Here we introduce a noninvasive optical method based on simultaneous recordings using NIRS, white light spectroscopy and LDF, combined with wavelet-based phase coherence analysis. Signals were recorded simultaneously for individuals in two groups of healthy subjects, 16 from Sub-Saharan Africa (BA group) and 16 Europeans (CA group). It was found that the power of myogenic oscillations in oxygenated and de-oxygenated hemoglobin is higher in the BA group, but that the phase coherence between blood flow and oxygen saturation, or blood flow and hemoglobin concentrations is higher in the CA group