A facile analytical method for reliable selectivity examination in cofactor NADH regeneration

Saba, Tony and Burnett, Joseph and Li, Jianwei and Kechagiopoulos, Panagiotis N. and Wang, Xiaodong (2020) A facile analytical method for reliable selectivity examination in cofactor NADH regeneration. Chemical Communications, 56 (8). pp. 1231-1234. ISSN 1359-7345

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Abstract

This study demonstrates a novel method to quantify selective (1,4-NADH) and unselective products (1,2- and 1,6-NADH) in NADH regeneration using combined UV-Vis spectroscopy and biological assays. The validity of the proposed method was tested in the Pt/C promoted NAD+ hydrogenation using hydrogen as reducing agent.