Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses

Dziadek, Michal and Douglas, Timothy and Dziadek, Kinga and Zagrajczuk, Barbara and Serafim, Andrada and Stancu, Izabela-Cristina and Cholewa-Kowalska, Katarzyna (2020) Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses. Materials Letters, 261. ISSN 0167-577X

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Abstract

In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes.

Item Type:
Journal Article
Journal or Publication Title:
Materials Letters
Additional Information:
This is the author’s version of a work that was accepted for publication in Materials Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Letters, 261, 2020 DOI: 10.1016/j.matlet.2019.127115
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3104
Subjects:
ID Code:
139472
Deposited By:
Deposited On:
10 Dec 2019 09:20
Refereed?:
Yes
Published?:
Published
Last Modified:
04 Jul 2020 06:09