In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

Leone, Federica and Firlak, Melike and Challen, Kirsty and Bonnefin, Wayne and Onida, Barbara and Wright, Karen and Hardy, John (2019) In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications. Journal of Functional Biomaterials, 10 (4). ISSN 2079-4983

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Abstract

In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Functional Biomaterials
Subjects:
ID Code:
138981
Deposited By:
Deposited On:
14 Nov 2019 14:30
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Nov 2020 08:08