CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading

Ding, H. and Wu, L. and Guo, T. and Zhang, Z. and Garba, B.M. and Gao, G. and He, S. and Zhang, W. and Chen, Y. and Lin, Y. and Liu, H. and Anwar, J. and Zhang, J. (2019) CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading. Crystal Growth and Design, 19 (7). pp. 3888-3894. ISSN 1528-7483

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Abstract

Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.

Item Type:
Journal Article
Journal or Publication Title:
Crystal Growth and Design
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3104
Subjects:
ID Code:
138450
Deposited By:
Deposited On:
24 Jun 2020 13:30
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Oct 2020 07:52