Liquid-liquid phase equilibria of aqueous biphasic systems based on glycerol formal:Application on tetracycline recovery from water

Praikaew, W. and Kiatkittipong, W. and Kiatkittipong, K. and Assabumrungrat, S. and Aiouache, F. and Najdanovic-Visak, V. (2019) Liquid-liquid phase equilibria of aqueous biphasic systems based on glycerol formal:Application on tetracycline recovery from water. Journal of Chemical and Engineering Data, 64 (11). pp. 4856-4862. ISSN 0021-9568

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Abstract

Biopharmaceuticals are commonly present in relatively low concentrations in aqueous solutions, making their detection and purification detrimental. In this work, we used novel aqueous biphasic systems based on glycerol formal (GF) to extract an important antibiotic - tetracycline. We report cloud points (solubility curve) and tie-lines for three ternary systems, containing GF, water, and inorganic salt (either K 3PO 4, K 2HPO 4, or K 2CO 3) at constant temperature of 298 K and at 0.1 MPa. The tie-line data of these ternary systems were correlated using the nonrandom two-liquid model, and binary interaction parameters of activity coefficients were estimated. The experimental and correlated tie-line data were compared in terms of average root-mean-square deviation and showed satisfactory agreements. The partition coefficients of tetracycline between two phases were measured, and corresponding extraction efficiencies were calculated. The maximum value of partition coefficient was 1551 for the system containing K 3PO 4, followed by values of 1145 and 927 for systems containing K 2CO 3 and K 2HPO 4, respectively. The calculated extraction efficiencies were very high - greater than 98.8%, demonstrating high potential for using aqueous biphasic systems based on GF for separation and purification processes.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Chemical and Engineering Data
Additional Information:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Chemical and Engineering Data, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.jced.9b00376
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600
Subjects:
ID Code:
138448
Deposited By:
Deposited On:
05 Nov 2019 11:40
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 05:45