Childhood Adversity and Borderline Personality Disorder:A Meta-Analysis

Porter, Carly and Palmier-Claus, Jasper and Branitsky, Alison and Mansell, Warren and Warwick, Helen and Varese, Filippo (2019) Childhood Adversity and Borderline Personality Disorder:A Meta-Analysis. Acta Psychiatrica Scandinavica. ISSN 0001-690X (In Press)

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Objective: The aim of this meta-analysis was to better understand the magnitude and consistency of the association between childhood adversity and borderline personality disorder (BPD) across case-control, epidemiological and prospective cohort studies. Method: Following the review protocol (reference: CRD42017075179), search terms pertaining to adversity and BPD, were entered into three search engines. Random effects meta-analysis synthesised the size and consistency of the effects. Results: 97 studies compared BPD to non-clinical (k = 40) and clinical (k = 70) controls. Meta-analysis of case control studies indicated that individuals with BPD are 13.91 (95% CI 11.11-17.43) times more likely to report childhood adversity than non-clinical controls. This effect was smaller when considering retrospective cohort (OR: 2.59; 95% CI .93-7.30) and epidemiological (OR: 2.56, 95% CI 1.24-5.30) studies. Findings were significant across adversity subtypes with emotional abuse (OR: 38.11, 95% CI: 25.99-55.88) and neglect (OR: 17.73, 95% CI=13.01-24.17) demonstrating the largest effects. Individuals with BPD were 3.15 (95% CI 2.62-3.79) times more likely to report childhood adversity than other psychiatric groups. Conclusions: This meta-analysis corroborates theoretical proposals that exposure to adverse life experiences is associated with BPD. It highlights the importance of considering childhood adversity when treating people diagnosed with BPD.

Item Type: Journal Article
Journal or Publication Title: Acta Psychiatrica Scandinavica
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2738
Departments: Faculty of Health and Medicine > Health Research
ID Code: 138055
Deposited By: ep_importer_pure
Deposited On: 21 Oct 2019 09:25
Refereed?: Yes
Published?: In Press
Last Modified: 20 Jan 2020 04:04

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