Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation

Sun, Yedi and Zhang, Guohua and Hawkes, Cheryl A. and Shaw, James E. and McLaurin, Jo Anne and Nitz, Mark (2008) Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation. Bioorganic and Medicinal Chemistry, 16 (15). pp. 7177-7184. ISSN 0968-0896

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Abstract

scyllo-Inositol has shown promise as a potential therapeutic for Alzheimer's disease, by directly interacting with the amyloid β (Aβ) peptide to inhibit Aβ42 fiber formation. To explore the molecular details of the inositol-Aβ42 interaction, a series of scyllo-inositol derivatives have been synthesized which contain deoxy, fluoro, chloro, and methoxy substitutions. The effects of these compounds on the aggregation cascade of Aβ42 have been investigated using electron microscopy (EM). EM analyses revealed that the 1-deoxy-1-fluoro- and 1,4-dimethyl-scyllo-inositols significantly inhibit the formation of Aβ42 fibers. The other derivatives showed some alterations in the morphology of the Aβ42 fibers produced. These findings indicate the importance of all of the hydroxyl groups of scyllo-inositol for complete inhibition of Aβ aggregation.

Item Type:
Journal Article
Journal or Publication Title:
Bioorganic and Medicinal Chemistry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
137320
Deposited By:
Deposited On:
04 Oct 2019 14:10
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2020 09:45