Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease

Dorr, Adrienne and Sahota, Bhupinder and Chinta, Lakshminarayan V. and Brown, Mary E. and Lai, Aaron Y. and Ma, Keran and Hawkes, Cheryl A. and McLaurin, Joanne and Stefanovic, Bojana (2012) Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease. Brain, 135 (10). pp. 3039-3050. ISSN 0006-8950

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The majority of patients with Alzheimer's disease have cerebral amyloid angiopathy, thus showing deposition of amyloid-β peptides in the walls of leptomeningeal and cortical arterioles. These deposits are believed to result from impaired clearance of parenchymal amyloid-β peptides. In the current work, we examined the changes in cortical microvascular structure and function in situ in TgCRND8, a transgenic mouse model of Alzheimer's disease. In contrast to venules, cortical arterioles were shown to increase in tortuosity and decrease in calibre with amyloid-β peptide accumulation. These structural changes were accompanied by progressive functional compromise, reflected in higher dispersion of microvascular network transit times, elongation of the transit times, and impaired microvascular reactivity to hypercapnia in the transgenic mice. Moreover, inhibition of amyloid-β peptide oligomerization and fibrillization via post-weaning administration of scyllo-inositol, a naturally occurring stereoisomer of myo-inositol, rescued both structural and functional impairment of the cortical microvasculature in this Alzheimer's disease model. These results demonstrate that microvascular impairment is directly correlated with amyloid-β accumulation and highlight the importance of targeting cerebrovascular amyloid angiopathy clearance for effective diagnosis, monitoring of disease progression and treatment of Alzheimer's disease.

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07 Oct 2019 08:35
Last Modified:
21 Sep 2023 02:43