The cerebrovascular basement membrane:Role in the clearance of β-amyloid and cerebral amyloid angiopathy

Morris, Alan W.J. and Carare, Roxana O. and Schreiber, Stefanie and Hawkes, Cheryl A. (2014) The cerebrovascular basement membrane:Role in the clearance of β-amyloid and cerebral amyloid angiopathy. Frontiers in Aging Neuroscience, 6 (SEP). ISSN 1663-4365

Full text not available from this repository.

Abstract

Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) brains and is thought to be due to a failure of the aging brain to clear Aβ. Perivascular drainage of Aβ along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which Aβ is removed from the brain. CVBMs are specialized sheets of extracellular matrix that provide structural and functional support for cerebral blood vessels. Changes in CVBM composition and structure are observed in the aged and AD brain and may contribute to the development and progression of CAA. This review summarizes the properties of the CVBM, its role in mediating clearance of interstitial fluids and solutes from the brain, and evidence supporting a role for CVBM in the etiology of CAA.

Item Type:
Journal Article
Journal or Publication Title:
Frontiers in Aging Neuroscience
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2805
Subjects:
ID Code:
137300
Deposited By:
Deposited On:
07 Oct 2019 08:50
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 05:41