Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma

Bueche, Celine Z. and Hawkes, Cheryl and Garz, Cornelia and Vielhaber, Stefan and Attems, Johannes and Knight, Robert T. and Reymann, Klaus and Heinze, Hans Jochen and Carare, Roxana O. and Schreiber, Stefanie (2014) Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma. Annals of Clinical and Translational Neurology, 1 (2). pp. 124-129. ISSN 2328-9503

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Abstract

There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Ab from the brain and hypertension is a wellknown risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.

Item Type:
Journal Article
Journal or Publication Title:
Annals of Clinical and Translational Neurology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2728
Subjects:
ID Code:
137298
Deposited By:
Deposited On:
07 Oct 2019 08:50
Refereed?:
Yes
Published?:
Published
Last Modified:
12 Aug 2020 09:35