High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

Lawman, Samuel and Dong, Yue and Williams, Bryan M. and Romano, Vito and Kaye, Stephen and Harding, Simon P. and Willoughby, Colin and Shen, Yao Chun and Zheng, Yalin (2016) High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography. Optics Express, 24 (11). pp. 12395-12405. ISSN 1094-4087

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Abstract

We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts.

Item Type:
Journal Article
Journal or Publication Title:
Optics Express
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3107
Subjects:
ID Code:
136988
Deposited By:
Deposited On:
24 Sep 2019 14:50
Refereed?:
Yes
Published?:
Published
Last Modified:
17 Jun 2020 07:30