Deformation velocity imaging using optical coherence tomography and its applications to the cornea

Lawman, Samuel and Madden, Peter W. and Romano, Vito and Dong, Yue and Mason, Sharon and Williams, Bryan M. and Kaye, Stephen B. and Willoughby, Colin E. and Harding, Simon P. and Shen, Yao Chun and Zheng, Yalin (2017) Deformation velocity imaging using optical coherence tomography and its applications to the cornea. Biomedical Optics Express, 8 (12). pp. 5579-5593. ISSN 2156-7085

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Abstract

Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.

Item Type:
Journal Article
Journal or Publication Title:
Biomedical Optics Express
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3107
Subjects:
ID Code:
136978
Deposited By:
Deposited On:
23 Oct 2019 10:25
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Oct 2020 07:44