Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

UNSPECIFIED (2019) Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51 (4). pp. 659-674. ISSN 1061-4036

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Abstract

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

Item Type:
Journal Article
Journal or Publication Title:
Nature Genetics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1311
Subjects:
?? geneticsgenetics ??
ID Code:
135893
Deposited By:
Deposited On:
06 Aug 2019 13:00
Refereed?:
Yes
Published?:
Published
Last Modified:
31 Dec 2023 01:06