Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment

Wilcockson, Thomas and Mardanbegi, Diako and Xia, Baiqiang and Taylor, Simon and Sawyer, Pete and Gellersen, Hans and Leroi, Ira and Killick, Rebecca and Crawford, Trevor (2019) Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment. Aging, 11 (15). pp. 5389-5398. ISSN 1945-4589

Full text not available from this repository.

Abstract

Background: There is increasing evidence that people in the early stages of Alzheimer’s disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.

Item Type:
Journal Article
Journal or Publication Title:
Aging
Subjects:
ID Code:
135719
Deposited By:
Deposited On:
23 Jul 2019 15:15
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 05:29