Mitonuclear gene X environment effects on lifespan and health:How common, how big?

Drummond, Emma and Short, Emma and Clancy, David (2019) Mitonuclear gene X environment effects on lifespan and health:How common, how big? Mitochondrion, 49. pp. 12-18. ISSN 1567-7249

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Mitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, modifiable by nucleotype but less so by diet. Finally, mitotype affected fly lifespan much more in a cage environment compared with a vial, also modifiable by nucleotype and diet. The cage may represent a stressful environment. Mitochondrial genotype may affect fitness much more in conditions of stress, which may have implications for human health.

Item Type: Journal Article
Journal or Publication Title: Mitochondrion
Additional Information: This is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 49, 2019 DOI: 10.1016/j.mito.2019.06.009
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1312
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 135518
Deposited By: ep_importer_pure
Deposited On: 26 Jul 2019 13:30
Refereed?: Yes
Published?: Published
Last Modified: 18 Sep 2019 03:11

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