Molecular evolution of peste des petits ruminants virus

Muniraju, Murali and Munir, Muhammad and Parthiban, Aravindhbabu R. and Banyard, Ashley C. and Bao, Jingyue and Wang, Zhiliang and Ayebazibwe, Chrisostom and Ayelet, Gelagay and El Harrak, Mehdi and Mahapatra, Mana and Libeau, Geneviève and Batten, Carrie and Parida, Satya (2014) Molecular evolution of peste des petits ruminants virus. Emerging Infectious Diseases, 20 (12). pp. 2023-2033. ISSN 1080-6040

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Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome sequences of all 4 lineages of the virus to investigate evolutionary and epidemiologic dynamics of PPRV. A Bayesian phylogenetic analysis of all PPRV lineages mapped the time to most recent common ancestor and initial divergence of PPRV to a lineage III isolate at the beginning of 20th century. A phylogeographic approach estimated the probability for root location of an ancestral PPRV and individual lineages as being Nigeria for PPRV, Senegal for lineage I, Nigeria/Ghana for lineage II, Sudan for lineage III, and India for lineage IV. Substitution rates are critical parameters for understanding virus evolution because restrictions in genetic variation can lead to lower adaptability and pathogenicity.

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Journal Article
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Emerging Infectious Diseases
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22 Jun 2019 09:18
Last Modified:
20 Sep 2023 01:23