Emergence of Lineage IV Peste des Petits Ruminants Virus in Ethiopia:Complete Genome Sequence of an Ethiopian Isolate 2010

Muniraju, M. and Mahapatra, M. and Ayelet, G. and Babu, A. and Olivier, G. and Munir, M. and Libeau, G. and Batten, C. and Banyard, A. C. and Parida, S. (2016) Emergence of Lineage IV Peste des Petits Ruminants Virus in Ethiopia:Complete Genome Sequence of an Ethiopian Isolate 2010. Transboundary and Emerging Diseases, 63 (4). pp. 435-442. ISSN 1865-1674

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Abstract

Isolates of peste des petits ruminants virus (PPRV) can be segregated genetically into four lineages. For decades, lineages I-III have been reported across Africa whilst lineage IV has predominantly circulated across Asia. However, the lineage distribution is currently changing in Africa. Importantly, full genome sequence data for African field isolates have been lacking. Here, we announce the first complete genome sequence of a field isolate of peste des petits ruminants virus (PPRV) from East Africa. This isolate was derived from the intestine of a goat suffering from severe clinical disease during the 2010 outbreak in Ethiopia. The full genome sequence of this isolate, PPRV Ethiopia/2010, clusters genetically with other lineage IV isolates of PPRV, sharing high levels of sequence identity across the genome. Further, we have carried out a phylogenetic analysis of all of the available African partial N gene and F gene PPRV sequences to investigate the epidemiology of PPRV with a focus on the emergence of different lineages of PPRV in Africa.

Item Type:
Journal Article
Journal or Publication Title:
Transboundary and Emerging Diseases
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3400
Subjects:
ID Code:
134772
Deposited By:
Deposited On:
22 Jun 2019 09:18
Refereed?:
Yes
Published?:
Published
Last Modified:
29 Jul 2020 05:39