Interaction of infectious bursal disease virus with the immune system of poultry

Rehman, Z. U. and Meng, C. and Umar, S. and Munir, M. and Ding, C. (2016) Interaction of infectious bursal disease virus with the immune system of poultry. World's Poultry Science Journal, 72 (4). pp. 805-820. ISSN 0043-9339

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Abstract

Immune dysfunction can be either at the humoral or cellular levels and is mediated by a myriad of factors including virus-induced immunosuppression. Infectious bursal disease virus (IBDV) affects domesticated poultry and causing health problems mainly due to prolonged immunosuppression. Destruction of the immunoglobulin-producing cells is the principal cause of IBDV-induced immunosuppression, which leads to significant impairment of the primary antibody responses. Due to these effects, IBDV infection not only increases the susceptibility of poultry to other viral infections but predisposes the host to several other bacteria of variable pathologies. The IBDV-induced immune-suppression is well-known phenomenon, however, recently there have been significant advancements in understanding the molecular mechanisms of this immune-suppression. This review discuss current updates regarding the immunotoxic and immunosuppressive nature of IBDV in the poultry and highlights areas requiring future research attentions that may help to establish foundations for effective and improved vaccines against IBDV.

Item Type:
Journal Article
Journal or Publication Title:
World's Poultry Science Journal
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1100/1103
Subjects:
ID Code:
134771
Deposited By:
Deposited On:
22 Jun 2019 09:18
Refereed?:
Yes
Published?:
Published
Last Modified:
13 May 2020 06:28